Saturday, May 29, 2010

Columbia University Medical Center Press Release

Columbia University Medical Center Press Release

Body’s Own Stem Cells Can Lead to Tooth Regeneration


Work at Columbia University College of Dental Medicine Holds Promise for a Biological Substitute for Dental Implants, According to Latest Journal of Dental Research

NEW YORK (May 19, 2010) - A technique pioneered in the Tissue Engineering and Regenerative Medicine Laboratory of Dr. Jeremy Mao, the Edward V. Zegarelli Professor of Dental Medicine at Columbia University Medical Center, can orchestrate stem cells to migrate to a three-dimensional scaffold infused with growth factor, holding the translational potential to yield an anatomically correct tooth in as soon as nine weeks once implanted.

People who have lost some or all of their adult teeth typically look to dentures, or, more recently, dental implants to improve a toothless appearance that can have a host of unsettling psycho-social ramifications. Despite being the preferred (but generally painful and potentially protracted) treatment for missing teeth nowadays, dental implants can fail and are unable to “remodel” with surrounding jaw bone that undergoes necessary changes throughout a person’s life.

Human Molar Scaffold
Human molar scaffolding from the lab of Dr. Jeremy Mao

An animal-model study has shown that by homing stem cells to a scaffold made of natural materials and integrated in surrounding tissue, there is no need to use harvested stem cell lines, or create an environment outside of the body (e.g., a Petri dish) where the tooth is grown and then implanted once it has matured. The tooth instead can be grown “orthotopically,” or in the socket where the tooth will integrate with surrounding tissue in ways that are impossible with hard metals or other materials.

"These findings represent the first report of regeneration of anatomically shaped tooth-like structures in vivo, and by cell homing without cell delivery,” Dr. Mao and his colleagues say in the paper. "The potency of cell homing is substantiated not only by cell recruitment into scaffold microchannels, but also by the regeneration of periodontal ligaments and newly formed alveolar bone."

This study is published in the most recent Journal of Dental Research, the top-rated, peer-reviewed scientific journal dedicated to the dissemination of new knowledge and information on all sciences relevant to dentistry, the oral cavity and associated structures in health and disease.

Dental implants usually consist of a cone-shaped titanium screw with a roughened or smooth surface and are placed in the jaw bone. While implant surgery may be performed as an outpatient procedure, healing times vary widely and successful implantation is a result of multiple visits to different clinicians, including general dentists, oral surgeons, prosthodontists and periodontists. Implant patients must allow two to six months for healing and if the implant is installed too soon, it is possible that the implant may fail. The subsequent time to heal, graft and eventually put into place a new implant may take up to 18 months.

The work of Dr. Mao and his laboratory, however, holds manifold promise: a more natural process, faster recovery times and a harnessing of the body’s own potential to re-grow tissue that will not give out and could ultimately last the patient’s lifetime.

Mao
Jeremy Mao, D.D.S., Ph.D.

“A key consideration in tooth regeneration is finding a cost-effective approach that can translate into therapies for patients who cannot afford or who aren’t good candidates for dental implants,” Dr. Mao says. “Cell-homing-based tooth regeneration may provide a tangible pathway toward clinical translation.”

Dr. Ira B. Lamster, dean of the College of Dental Medicine, stated: “This research provides an example of what is achievable when today’s biology is applied to common clinical problems. Dr. Mao’s research is a look into the future of dental medicine.”

This research was supported by NIH ARRA Funding via 5RC2 DE020767 from the National Institute of Dental and Craniofacial Research. Columbia has filed patent applications relating to the engineered tooth and, through its technology transfer office, Columbia Technology Ventures, is actively seeking partners to help commercialize the technology.

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Friday, May 28, 2010

Education Webinars (1CE, no charge)



Should be 6.00am in India.

 

 
 
Upcoming Educational Webinars
1CE, No Charge 
 
"Blue Sky Plan Training"
June 14th, 2010 REGISTER NOW
9:00PM Eastern, 8:00PM Central, 7:00PM Mountain, 6:00PM Pacific
 
This course will introduce Blue Sky Bio's full featured treatment planning software and the Computer Guided Surgical Template process flow. The course will include technical  training on using the software to load and prepare a treatment plan. The presentation will also present the upcoming software upgrade release and its new features.
 
---------------------------------------------------------------------------
 
"Clinical Treatment Planning"
July 12th, 2010 7:00pm Eastern
    REGISTER NOW
9:00PM Eastern, 8:00PM Central, 7:00PM Mountain, 6:00PM Pacific
 
Submit your case for analysis and treatment planning.  Joe Ambrose C.D.T, the Technical Director at ROE Dental  will select several cases to analyze and discuss proper treatment planning techniques for optimal surgical and restorative considerations. Mr Ambrose has vast experience treatment planning countless cases.  Cases will be accepted in the Blue Sky Plan treatment planning software (download).
To submit a case for possible analysis during the webinar please send the scan / treatment plan, case plan and a description of the case's challenges to 
plan@blueskybio.com. Cases can be submitted until June 30th 2010. 
 
 


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--
Dr.C.P.Mathai MDS
Oral Surgery, Dental Implants, Oral Reconstruction.
Restoring Smiles! Building Confidence!
http://www.implantsutra.com

Friday, May 21, 2010

Ordering Stents for Computer Guided Surgery

Illusion Dental In Mumbai is now fabricating surgical guides for the Blue Sky Bio System

Blue Sky Plan Surgical Templates can be ordered from
ROE Dental Lab (United States)
http://www.roedentallab.com/
BJ@RoeDentalLab.com
800.228.6663

nSequence Center for Advanced Dentistry (United States)
http://www.nsequence.com
drl@sequencedental.com
888.809.2777

Raydent Biotechnology Corporation (Taiwan)
http://www.raydentbio.com/
raydent_co@yahoo.com.tw
+886 2 23702100

Illusion Dental Lab (India)
http://www.illusiondentallab.com
Sameerkmerchant@aol.com
[00 91 22] 61437900

Promidental Dental Services (Europe and Int'l)
http://www.promidental.com
info@promidental.com
320.315.4605

*prices in the USA. See www.BlueSkyBio.com for details


This message was sent from Blue Sky Bio to cpmathai@gmail.com. It was sent from: Michael Saltzman, 888 E Belvidere Road, Glayslake, IL 60030. You can modify/update your subscription via the link below.

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--
Dr.C.P.Mathai MDS
Oral Surgery, Dental Implants, Oral Reconstruction.
Restoring Smiles! Building Confidence!
http://www.implantsutra.com